PVI®Pleth Variability Index

Pleth Variability Index (PVI®) is a breakthrough measurement that may help clinicians noninvasively and continuously assess fluid status of patients.


  • > Fluid administration is critical
    • To increase cardiac output and optimize patient status, enabling end organ preservation1
  • > Unnecessary fluid administration associated with increased morbidity and mortality2
    • Fluid administration causes hemodilution, which reduces Hb concentration and increases likelihood of transfusion3
  • > Traditional static measurements not reliable to predict volume responsiveness
    • CVP, SBP, DBP, Pulse Pressure, Wedge Pressure, Cardiac output4
  • > New dynamic monitoring technologies are effective
    • Proven to improve outcomes but are invasive or complex - and costly5
    • Examples: Pulse pressure variation, stroke volume variation
    • Appropriate for higher-risk patients
  • > There is a large opportunity to improve care in moderate to low risk population
    • Using low cost, noninvasive technology
  • > PVI has been shown to help clinicians:
    • Predict fluid responsiveness in mechanically ventilated patients under general anesthesia during surgery and in the ICU in adults6,7 and children8
    • Improve fluid management and decrease lactate levels compared to standard care9

"PVI demonstrated high accuracy in discriminating fluid responders from non-responders—providing a unique opportunity to better manage a patient's fluid volume to optimize cardiac performance and organ perfusion."

Maxime Cannesson, MD
Associate Professor of Anesthesiology
in the Department of Anesthesiology &
Perioperative Care at the University of California, Irvine

Dr. Maxime Cannesson on the clinical value of PVI

Technology Platform

Masimo rainbow® is a noninvasive monitoring platform enabling the assessment of multiple blood constituents and physiologic parameters that previously required invasive or complicated procedures, in addition to providing Masimo SET® Measure-through Motion and Low Perfusion™ pulse oximetry.

Masimo Radical-7 upgraded with RRa

  • > Total Hemoglobin (SpHb®)
  • > Carboxyhemoglobin (SpCO®)
  • > Methemoglobin (SpMet®)
  • > Oxygen Content (SpOC)
  • > Acoustic Respiration Rate (RRa)
  • > Oxygen Saturation (SpO2)
  • > Pulse Rate (PR)
  • > Perfusion Index (PI)
  • > Pleth Variability Index (PVI®)

The upgradeable rainbow® platform lets you choose the rainbow® measurements that are right for you now and be confident that your investment in patient safety won’t become obsolete tomorrow.

PDF Resources

Masimo SEDLine brochure Data Sheet:
Pleth Variability Index
Masimo pvi Technical Bulletin:
Pleth Variability Index


  • 1 Perel A. Anesth Analg. 2008; 106 (4):1031-33
  • 2 Bundgaard-Nielsen M et al. Acta Anaesthesiol Scand. 2007; 51(3):331-40
  • 3 Huybregts RA et al. Anesth Analg.  2009.  109(2): 331-339.
  • 4 Michard F et al. Chest. 2002; 121(6):2000-08
  • 5 Joshi G et al. Anesth Analg. 2005; 101:601-5.
  • 6 Cannesson M. et al. Br J Anaesth. 2008;101(2):200-6.
  • 7 Loupec T. et al. Crit Care Med. 2011;39(2):294-299.
  • 8 Byon H et al. BJA 2012 December; DOI 10.1093/bja/aes467
  • 9 Forget P. et al. Anesth Analg. 2010;111(4):910-4.